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HomeGreat Overnight StopsGreat Overnight Stop: Santee, SC (I-95, Exit 98)

Great Overnight Stop: Santee, SC (I-95, Exit 98)

Traveling from Southern Pennsylvania, Southern New Jersey or Delaware and Southern Florida and need a halfway point? Santee, South Carolina make a Great Overnight Stop!

Santee, South Carolina is a great overnight stop. Why? Consider this… you’ve traveled all day, you’re tired, hungry, the kids are wired… you get the picture. What you really need right about then is that perfect overnight stop… an exit where you feel safe and comfortable… an exit with a good mix of accommodations and a variety of eating places… not just fast food. And, maybe a little shopping later before you get back to the motel. The next morning you can gas up nearby and head out. Everything you need conveniently located right off the exit! That’s what makes this Santee, South Carolina exit a great overnight stops!

About Santee, South Carolina…

Santee is a town in Orangeburg County along the Santee River Valley in central South Carolina. It has become a resort town of note located centrally north-south along the Atlantic Seaboard of South Carolina. The region has been rural, with a primarily agricultural economy typical of Orangeburg County, but is now known primarily for its several golf courses in proximity to Lake Marion, Santee State Park and other Lake Marion attractions. Interstate 95 connects its attractions easily with tourists traveling by automobile. I-95 crosses a narrow arm of the lake into the town lands, along a causeway. Lake Marion is a man-made hydroelectric reservoir, which at 110,000 acres is one of the fifty largest lakes in the country. Wikipedia

Where to Stay in Santee…

There are over a dozen lodging choices at this Santee exit. That means two things… you can probably find just the right place that meets your needs, and the prices are competitive! Here’s what’s available at this exit:

Baymont Inn, Best Western Plus Santee Inn, Clarion Inn, Clark’s Inn, Comfort Inn and Suites, Econo Lodge, Fairfield Inn and Suites, Hampton Inn, Holiday Inn, Knights Inn, Lake Marion Inn, Quality Inn and Suites, Red Roof Inn, Super 8, and Travelodge.

Holiday Inn, Santee, SC | I-95 Exit Guide
Holiday Inn in Santee, South Carolina

Where to Eat in Santee…

There’s no shortage of variety at this Santee exit. From casual sit-down to fast food, and everything in between. You’ll find the following dining opportunities here:

Armado’s Mexican Restaurant, Bojangle’s, Captain’s Quarters Seafood and Steak, China Dragon, Clark’s Restaurant, Cracker Barrel Old Country Store, Craig’s Place Seafoods and Deli, Huddle House, I-95 Bar and Grill, Ice Cream Bar, McDonald’s, Pizza Hut, Santee Seafood Bistro, Sub Station, Subway, Taco Bell, Thai House Restaurant, Waffle House, Wendy’s, Wilber’s Supper Club, and Ziggy’s Bar and Grill.

Clark's Inn and Restaurant, Santee, SC | I-95 Exit Guide
Clark’s Inn and Restaurant in Santee, South Carolina

Where to Shop in Santee…

This exit has a good selection of shopping opportunities. You’ll find the following here:

CVS Pharmacy, Dollar General, Family Dollar, Food Lion Supermarket, and Santee IGA.

Fuel Up and Head Out…

Like we always say, quantity means competition and with this many gas stations, prices are bound to be competitive. You’ll find the following gas stations at this exit:

BP, Chevron, Citgo, Exxon, Hess, Horizon, Mobil, Shell

66 miles north is Florence, SC, another recommended stopover exit.

41 miles south is Walterboro, SC, another recommended stopover exit.

The I-95 Exit Guide is the Internet’s largest and most complete website dedicated to Interstate 95 travelers. Find detailed exit service listings… lodging, camping, food, gas and more for every exit from Maine to Florida!

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Traveling another route? Visit our growing family of exit guides:  I-4 Exit GuideI-5 Exit GuideI-10 Exit GuideI-75 Exit GuideI-80 Exit Guide and I-95 Exit Guide. Detailed exit service listings… discount lodging, camping, food, gas and more for every exit along the way!


  1. This is a town with a lot of hotels, but very few sit down and dine restaurants with bars. The Captain’s Quarters with a bar closes at 9:00 pm as does the horrible Clarks’s Restaurant and Pub. Pedro’s closes at 10:00 pm. After driving on I-95 for almost 12 hours, and pulling into Santee at 9:20 pm we were shocked that the town had gone to sleep.

  2. We have been driving to Florida for over 30 years and regularly stop for the night in Santee. There are some good hotels and restaurants at this exit… and the gas is cheap too!

  3. I grew up visiting the area every summer…my grandparents and extended family lived in Eutawville area. Now when I visit family with my children and grandchildren, Santee is definitely where we stay because it’s so convenient and close to all our relatives!


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I-95 Exit Guide
I-95 Exit Guide
The I-95 Exit Information Guide is one of the most popular travel destinations on the Internet. This website features detailed listings for exit services all along Interstate 95, from Maine to Florida.

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