South Carolina lodging located within 1/2 mile of an I-95 exit are listed below. These listings run north to south. Individual exits show intersecting routes and cities and towns accessible from that exit.
| Exit | Exit Description | Exit Services |
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| 193 | Rradford Boulevard, SC 9, SC 57, Dillon, Little Rock |
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| 181 | SC 38, SC 917, Bennetsville, Marion | |
| click here for dillon area hotel discounts | ||
| 169 | TV Road, Quimby, Florence |
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| click here for florence area hotel discounts | ||
| 164 | West Lucas Street, US 52, Florence, Darlington | Baymont by Wyndham, Best Western Inn, Clarion Inn & Suites, Comfort Suites, Country Inn & Suites, Days Inn, EconoLodge, Florence Travelhouse Inn, Hampton Inn & Suites, Howard Johnson by Wyndham, Knights Inn, La Quinta Inn & Suites by Wyndham, MainStay Suites, Mictotel Inn & Suites by Wyndham, Motel 6, Park Inn by Raddison, Red Roof Inn, Sleep Inn, Studio 6, Suburban Studios, Super 8, Tru by Hilton |
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| click here for columbia area hotel discounts | ||
| 160A/B | Junction I-20, Florence, Columbia (westbound I-20 is a limited access highway, services below are via eastbound I-20 spur), W. David McLeod Boulevard |
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| click here for florence area hotel discounts | ||
| 157 | West Palmetto Street, US 76, Florence, Timmonsville |
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| 150 | Cale Yarborough Highway, SC 403, Sardis, Timmonsville |
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| 146 | Lynches River Road, SC 341, Olanta, Lynchburg |
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| 135 | Myrtle Beach Highway, US 378, Turbeville, Sumter |
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| click here for sumter area hotel discounts | ||
| 119 | Paxville Highway, SC 261, Manning, Paxville |
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| click here for manning area hotel discounts | ||
| 115 | Alex Harvin Highway, US 301, Manning |
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| click here for summerton area hotel discounts | ||
| 108 | Buff Boulevard, Road 102, Summerton |
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| 102 | St. Paul Road, US 15, US 301, Road 400, North Santee | |
| click here for santee area hotel discounts | ||
| 98 | Old Number 6 Highway, SC 6, Eutawville, Santee | Baymont Inn, Best Western Plus Santee Inn, Clarion Inn, Clark’s Inn, Comfort Inn and Suites, Econo Lodge, Fairfield Inn and Suites, Hampton Inn, Holiday Inn, Lake Marion Inn, Quality Inn and Suites, Red Roof Inn, Super 8, Travelodge |
| 97 | US 301, Orangeburg | |
| 82 | US 178, Harleyville, Bowman |
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| click here for st george area hotel discounts | ||
| 77 | Jim Bilton Boulevard, US 78, St. George, Branchville |
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| 57 | Bells Highway, SC 64, Walterboro | Carolina Lodge, Sleep Inn, Super 8 by Wyndham, Travelodge by Wyndham |
| click here for walterboro area hotel discounts | ||
| 53 | Sniders Highway, SC 63, To US 17 Alt., Walterboro |
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| click here for yemassee area hotel discounts | ||
| 38 | SC 68, Yemassee, Hampton |
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| click here for beaufort area hotel discounts | ||
| 33 | Kings Highway, US 17, Charleston, Beaufort |
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| click here for ridgeland area hotel discounts | ||
| 22 | Jacob Smart Boulevard, US 17 South, Ridgeland |
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| click here for hilton head area hotel discounts | ||
| 21 | US 278, Ridgeland, Hilton Head Island |
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| 8 | Road 88, Beaufort |
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| click here for hardeeville area hotel discounts | ||
| 5 | US 17, US 321, Hardeeville, Estille |
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